The Alligator People (1959)

Horror, Sci-Fi,

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A newlywed couple sit in a train. The husband receives a frantic telegram. He gets off at a station to make a phone call, the train pulls away without him on it, and that's the last his wife sees of him. Years later after a long search she finally tracks him down on his family's southern estate where she discovers that a failed medical treatment has turned him into an alligator mutant.